What is Zonegran?
Zonegran is a sulfa drug with anti-convulsant effects.

Zonegran may also be used for other purposes not listed in this medication guide.

Important information about Zonegran

You may have thoughts about suicide while taking Zonegran. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Zonegran can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop taking Zonegran without first talking to your doctor, even if you feel fine. Stopping Zonegran suddenly may cause you to have seizures. You may need to use less and less before you stop the medication completely.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Zonegran.

Carry an ID card or wear a medical alert bracelet stating that you are taking Zonegran, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

Before taking Zonegran

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take Zonegran, tell your doctor if you have:

liver disease
kidney disease;
asthma or other breathing problems;
stomach flu or illness causing diarrhea; or
if you have been on a high-protein, low-carb diet.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before taking Zonegran, tell your doctor if you are pregnant or plan to become pregnant during treatment.

You may have thoughts about suicide while taking Zonegran. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

It is not known whether zonisamide passes into breast milk or if it could harm a nursing baby. Do not use Zonegran without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 16 years old without the advice of a doctor.

How should I take Zonegran?

Take Zonegran with a full glass of water. Drink 6 to 8 glasses of water each day to prevent kidney stones while you are taking this medicine.

Zonegran can be taken with or without food.

Swallow the Zonegran capsule whole. Do not crush, chew, open, or break it.

To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor.

Seizures are often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Do not stop taking Zonegran without first talking to your doctor, even if you feel fine. Stopping Zonegran suddenly may cause you to have seizures. You may need to use less and less before you stop the medication completely.

If you do stop taking Zonegran for any reason, talk with your doctor before restarting the medication. You may need to restart at a lower dose.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Zonegran.

Carry an ID card or wear a medical alert bracelet stating that you are taking Zonegran, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

Store Zonegran at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

What happens if I overdose?

Overdose symptoms may include slow heart rate, feeling light-headed, fainting, and slow or shallow breathing.

What should I avoid while taking Zonegran?

Zonegran side effects

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
the first sign of any skin rash, no matter how mild;
increased or worsening seizures;
rapid breathing or feeling short of breath with dry mouth, confusion, dizziness or weakness, numbness or tingling, chest pain;;
fast, pounding, or uneven heartbeats;
pale skin, easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips;
problems with thinking or speech, trouble concentrating;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
dizziness or weakness and hot, dry skin without sweating;
urinating less than usual or not at all; or
sudden back pain, stomach or side pain, pain or bleeding when urinating, bloody or dark urine.
Less serious Zonegran side effects may include:
drowsiness, dizziness, headache, tired feeling;
mild loss of appetite, weight loss;
loss of balance or coordination;
sore throat, cough; or
blurred vision, ringing in your ears.

What other drugs will affect Zonegran?

Tell your doctor about all other seizure medications you use, especially:
carbamazepine (Carbatrol, Tegretol);
phenytoin (Dilantin); or
phenobarbital (Solfoton).

This list is not complete and there may be other drugs that can interact with Zonegran. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

What does my medication look like?

Zonegran 100mg-red and white capsules