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1374 Estrofem (Estradiol)
Novo Nordisk
2mg
28 tabs
39.60
ma208 Estrofem (Generic Estradiol)
Novo Nordisk
Turkey
2mg
84 tabs
(3 x 28)
79.00

General Description & Use
Natural Oestrogen/ Estrogen. A female hormone used for the treatment of the oestrogen deficiency syndrome. Also popular for M2F transsexuals in gender reassignment.

List of estradiol medications
The following are marketed versions of estradiol:

Oral versions: Estrace, Activella (also contains a progestin), estradiol acetate, Progynova, Estrofem®, Zumenon
Transdermal preparation: Alora, Climara, Vivelle, Vivelle-Dot, Menostar, Estraderm TTS
Ointments: Estrasorb Topical, Estrogel, Elestrin
Injection: Estradiol cyprionate: Lunelle monthly injection, Estradiol valerate
Vaginal ointment: Estrace Vaginal Cream, Premarin Cream
Vaginal ring: Estring (estradiol acetate), Femring

Estradiol is also part of conjugated estrogen preparations, including Premarin but is not the major ingredient (Premarin consists of hundreds of estrogen derivatives due to its natural source...pregnant mare urine.

Buy Estrofem Zumenon Estradiol without PrescriptionEstradiol (17ß-estradiol) (also oestradiol) is a sex hormone. Mislabelled the "female" hormone, it is also present in males; it represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including bone structure. During the reproductive years, most estradiol in women is produced by the granulosa cells of the ovaries by the aromatization of androstenedione (produced in the theca folliculi cells) to estrone, followed by conversion of estrone to estradiol by 17ß-hydroxysteroid reductase. Smaller amounts of estradiol are also produced by the adrenal cortex, and (in men), by the testes. Estradiol is not only produced in the gonads: in both sexes, precursor hormones, specifically testosterone, are converted by aromatization to estradiol. In particular, fat cells are active to convert precursors to estradiol, and will continue to do so even after menopause. Estradiol is also produced in the brain and in arterial walls.

Estrofem® was especially developed and indicated for the treatment of oestrogen deficiency symptoms in women without a uterus, with effective symptom relief and good tolerability (continuous therapy with calendar pack of 28 tablets containing 1mg 17b-oestradiol). As there is no increased risk of developing cancer of the uterus lining in women without a uterus, they need not to take an additional progestogen. The drug is available in different dosages because a standardised unique dose is not optimal for every woman. Studies have demonstrated that after four weeks of treatment there is a significant reduction in hot flushes and other menopausal complaints. The administration of Estrofem® results in a significant increase of bone density.

Female reproduction
In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol that is produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy estradiol increases due to placental production.

Sexual development
The development of secondary sex characteristics in women is driven by estrogens, specifically estradiol. These changes are initiated at the time of puberty, most enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol enhances breast development, and is responsible for changes in the body shape affecting bones, joints, fat deposition. Fat structure and skin composition are modified by estradiol.

Bone
There is ample evidence that estradiol has a profound effect on bone. Individuals without estradiol (or other estrogens) will become tall and eunuchoid as epiphysieal closure is delayed or may not take place. Bone structure is affected resulting in early osteopenia and osteoporosis. Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.

Estradiol medication
Estrogen is marketed in a number of ways to address issues of hypoestrogenism. Thus there are oral, transdermal, topical, injectable, and vaginal preparations. Furthermore, the estradiol molecule may be linked to an alkyl group at C3 position to facilitate the administration. Such modifications give rise to estradiol acetate (oral and vaginal applications) and to estradiol cyprionate (injectable).

Oral preparations are not necessarily predictably absorbed and subject to a first pass through the liver where they can be metabolized and also initiate unwanted side effects. Thus, alternative routes of administration have been developed that bypass the liver before primary target organs are hit. Transdermal and transvaginal routes are not subject to the initial liver passage.

A more profound alteration is ethinylestradiol, the most common estrogen ingredient in combined oral contraceptive pills and available here at NPD in pure form.

Hormone replacement therapy (HRT)
If severe side effects of low levels of estradiol in a woman's blood are experienced (commonly at the beginning of menopause or after oophorectomy), hormone replacement therapy may be prescribed. Often such therapy is combined with a progestin.

Estrogen therapy may be used in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucus or an appropriate uterine lining. Estrogen therapy is also used to maintain female hormone levels in male-to-female transsexuals. Also see a list of all hormones available from NPD here.

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