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Strength
Pack Size
$ Price
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ma252 Estraderm TTS 100 (Generic Estradiol)
EU Turkey
8mg
16 (2 x 8) patches
69.38
ma253 Estraderm TTS 25 (Generic Estradiol)
EU Turkey
2mg
18 (3 x 6) patches
64.75
ma254 Estraderm TTS 50 (Generic Estradiol)
EU Turkey
4mg
18 (3 x 6) patches
76.50
1371 Estraderm TTS
Novartis
100mcg
8 patches
48.84
out of stock
1372 Estraderm TTS
Novartis
25mcg
8 patches
40.70
out of stock
1373 Estraderm TTS
Novartis
50mcg
8 patches
50.88
out of stock

General Description & Use
Treats the lack of estrogen from menopause or removal of the ovaries. Also used to treat osteoporosis (bone loss). Also popular for M2F transsexuals in gender reassignment. Estraderm TTS patches contain the active ingredient estradiol (previously spelt oestradiol in the UK), which is a naturally occuring form of the main female sex hormone, oestrogen.

About Estraderm Patches
Buy Estraderm PatchesWomens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, such as irregular periods, hot flushes, night sweats, mood swings and vaginal dryness or itching. Oestrogen (in this case in the form of estradiol) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). HRT is usually only required for short-term relief from menopausal symptoms and its use should be reviewed at least once a year with your doctor. Estraderm TTS patches are a continuous, oestrogen-only form of HRT. They release estradiol through the skin into the bloodstream at a constant rate and are designed to be changed twice a week, ie a patch is worn for three to four days and then replaced with a new one.
As they only contain oestrogen, Estraderm TTS patches are most suitable for women who have had a hysterectomy. Women who have not had a hysterectomy should also be prescribed a progestogen medicine to take with this medicine for the last 12 days of each monthly cycle. This is because oestrogen stimulates the growth of the womb lining (endometrium), which can lead to endometrial cancer if the growth is unopposed. A progestogen is given to oppose oestrogen's effect on the womb lining and reduce the risk of cancer, though it does not eliminate this risk entirely. This is known as combined HRT. If a woman has had her womb surgically removed (a hysterectomy), endometrial cancer is not a risk, and a progestogen is not necessary as part of HRT (unless the woman has a history of endometriosis).

HRT is also sometimes used to prevent osteoporosis in postmenopausal women. The declining level of oestrogen at menopause can affect the bones, causing them to become thinner and more prone to breaking. Oestrogen supplements help prevent bone loss and fractures that may occur in women in the years after menopause.

Buy Estraderm PatchesHowever, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits. As a result this medicine should not be used as a first-line option for preventing postmenopausal osteoporosis in women over 50. However, it may be used as a second-line option for women at high risk of fractures who cannot take other medicines that are licensed for this purpose. Only the Estraderm TTS 50 strength is licensed for preventing osteoporosis.

Women considered to be at risk of developing fractures following the menopause include those who have had an early menopause, those with a family history of osteoporosis, those who have had recent prolonged corticosteroid therapy (eg prednisolone), those with a small thin frame, and smokers.

You can read more about the risks and benefits of HRT and other medicines for preventing osteoporosis in the factsheets about menopause and osteoporosis linked below.

What is it used for?
Transdermal hormone replacement therapy to relieve symptoms of the menopause. Transdermal applied HRT (eg: hormones absorbed through the skin) are less stressful upon the liver than orally taken HRT.

Second-line option for preventing osteoporosis in postmenopausal women who are at high risk of fractures and cannot take other medicines licensed for preventing osteoporosis (Estraderm TTS 50 only).

Hormone treatment in male-to-female transsexuals

Also see Estrofem® Estradiol and Progynova (non synthetic and plant extracted estradiol) and a complete list of hormone related products

Warning!
Follow the instructions provided with your patches carefully. One Estraderm TTS patch should be applied to a clean, dry, unbroken, non-irritated area of skin below the waist, eg the buttocks. Don't apply creams, lotions or other oily products before applying the patch as they will stop it sticking. The patch should be replaced with a new one twice a week. Each fresh patch should be applied to a slightly different area to avoid irritating the skin. Leave at least a week before applying a patch to the same site. Patches should NOT be applied on or near the breasts. They should not be exposed to sunlight.

You can shower and bath without removing the patch. If a patch falls off before you are due to change it, for example because you have been doing vigorous exercise, sweating excessively, or wearing clothes that rub the patch, you should replace it with a new one. Change this new patch on your normal patch change day.

Women using any form of HRT should have regular medical and gynaecological check-ups. Your need for continued HRT should be reviewed with your doctor at least once a year.

It is important to be aware that all women using HRT have an increased risk of being diagnosed with breast cancer compared with women who don't use HRT. This risk needs to be weighed against the personal benefits to you of using HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. You should discuss these with your doctor before starting HRT. Women on HRT should have regular breast examinations and mammograms and should examine their own breasts regularly. Report any changes in your breasts to your doctor or nurse.

It is important to be aware that women using HRT have a slightly increased risk of stroke and of blood clots forming in the veins (eg deep vein thrombosis/pulmonary embolism) compared with women who don't use HRT. The risk is higher if you have existing risk factors (eg personal or family history, smoking, obesity, certain blood disorders - see cautions below) and needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. Discuss these with your doctor before starting treatment.

The risk of blood clots forming in the veins (thromboembolism) while using HRT may be temporarily increased if you experience major trauma, have surgery, or are immobile for prolonged periods of time (this includes travelling for over five hours). For this reason, your doctor may recommend that you stop using HRT for a period of time (usually four to six weeks) prior to any planned surgery, particularly abdominal surgery or orthopaedic surgery on the lower limbs, or if you are to be immobile for long periods. The risk of blood clots during long journeys may be reduced by appropriate exercise during the journey and possibly by wearing elastic hosiery. Discuss this with your doctor.

Stop using this medicine and inform your doctor immediately if you experience any of the following symptoms while using this medicine: stabbing pains or swelling in one leg; pain on breathing or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness affecting one side or part of the body; fainting; worsening of epilepsy; migraine or severe headaches; visual disturbances; severe abdominal complaints; increased blood pressure; itching of the whole body; yellowing of the skin or eyes (jaundice); or severe depression.

This medicine will not usually cause a monthly withdrawal bleed, unless you are also prescribed progestogen tablets to take for the last few days of each month. However, you may experience spotting or breakthrough bleeding during the first few months of treatment. Spotting or breakthrough bleeding is more likely if you forget to change a patch on schedule. If any bleeding continues after a few months of using the medicine, or after stopping treatment, you should consult your doctor.

A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT does not provide contraception for women who fall within this group. If a potentially fertile women is taking HRT but also requires contraception, a non-hormonal method (eg condoms or contraceptive foam) should be used.

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