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1108 Bactroban (Generic Mupirocin)
Gsk
Smith Kline
2% ointment
15mg
(3 x 5gm)
32.56
1109 Bactroban (Generic Mupirocin)
Gsk
Generic
2% cream
15g
40.70

General Description & Use
Buy Bactroban Generic Mupirocin without PrescriptionUsed to treat impetigo as well as other skin infections caused by bacteria. Mupirocin (Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin[6].

Mupirocin has been shown to strongly inhibit protein and RNA synthesis in Staphylococcus aureus while DNA and cell wall formation are also negatively impacted a lesser degree. The inhibition of RNA synthesis was shown to be a protective mechanism in response to a lack of one amino acid, isoleucine. In vivo studies in Escherichia coli demonstrated that pseudomonic acid inhibits isoleucine t-RNA synthetase (IleRS). This mechanism of action is shared with furanomycin, an analog of isoleucine.

Uses
Mupirocin is used as a topical treatment for bacterial skin infections, for example, furuncle, impetigo, open wounds etc. It is also useful in the treatment of methicillin-resistant Staphyolococcus aureus (MRSA), which is a significant cause of death in hospitalized patients who have received systemic antibiotic therapy. It is suggested, however, that mupirocin not be used for extended periods of time, or indiscriminately, as resistance does develop, and could, if it becomes widespread, destroy mupirocin's value as a treatment for MRSA. It may also result in overgrowth of non-susceptible organisms.

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